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A useful combination targets a different rate-limiting step in the same pathway

47 In addition, rodent GH does not activate the human or primate GHR, so the use of pegvisomant in animal models of disease does not address the effect of the blockade of systemic GH

The remission may only be temporary, particularly among children

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In models of Achilles tendon transection, the peptide accelerated healing and restored biomechanical properties to near-normal levels